Medicinal Chemistry Research

Synthesis and structure–antibacterial activity relationship studies of 4-substituted phenyl-4, 5-dihydrobenzo [f][1, 4] oxazepin-3 (2H)-thiones

H Agirbas, B Kemal, F Budak

Index: Agirbas, Hikmet; Kemal, Berat; Budak, Fatma Medicinal Chemistry Research, 2011 , vol. 20, # 8 p. 1170 - 1180

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Citation Number: 8

Abstract

Abstract The synthesis and characterization of a series of 4-substituted phenyl-4, 5- dihydrobenzo [f][1, 4] oxazepin-3 (2H)-thiones were presented. Preliminary in vitro antimicrobial activity of the compounds was assessed against a panel of microorganisms including S. aureus, E. faecalis, P. aeruginosa, E. coli, and C. albicans. Some of the compounds exhibited significantly in vitro antimicrobial activity. The p MIC values were ...