Design, synthesis, and biological activities of novel Ligustrazine derivatives

XC Cheng, XY Liu, WF Xu, XL Guo, Y Ou

Index: Cheng, Xian-Chao; Liu, Xin-Yong; Xu, Wen-Fang; Guo, Xiu-Li; Ou, Yang Bioorganic and Medicinal Chemistry, 2007 , vol. 15, # 10 p. 3315 - 3320

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Citation Number: 35

Abstract

A series of novel Ligustrazine derivatives was designed, synthesized, and assayed for their protective effects on damaged ECV-304 cells and antiplatelet aggregation activities. The results showed that most Ligustrazine derivatives exhibited lower EC50 values for protective effects on the ECV-304 cells damaged by hydrogen peroxide in comparison with Ligustrazine. And some Ligustrazine derivatives presented better antiplatelet aggregation ...