Potential inhibitors of nucleotide biosynthesis. 2. Halomethyl ketone derivatives of pyrimidine nucleosides

…, HJ Thomas, RW Brockman, RD Elliott

Index: Montgomery; Thomas; Brockman; Elliott Journal of Medicinal Chemistry, 1984 , vol. 27, # 5 p. 680 - 684

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Citation Number: 10

Abstract

A detailed rationale for the preparation of nucleosides containing a chemically reactive function attached through a spacer to C-5'that may act as active-site-directed, irreversible inhibitors of enzymes that metabolize the corre-sponding nucleotides has been pre~ ented.~ As a part of