Synthesis and biological evaluation of novel 5-benzylidenethiazolidine-2, 4-dione derivatives for the treatment of inflammatory diseases

…, J Chen, J Yang, N Qiu, G Wang, X Liang…

Index: Ma, Liang; Xie, Caifeng; Ma, Yinghua; Liu, Juan; Xiang, Mingli; Ye, Xia; Zheng, Hao; Chen, Zhizhi; Xu, Qinyuan; Chen, Tao; Chen, Jinying; Yang, Jincheng; Qiu, Neng; Wang, Guangcheng; Liang, Xiaolin; Peng, Aihua; Yang, Shengyong; Wei, Yuquan; Chen, Lijuan Journal of Medicinal Chemistry, 2011 , vol. 54, # 7 p. 2060 - 2068

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Citation Number: 29

Abstract

Twenty-two compounds based on thiazolidine-2, 4-dione moiety were synthesized and evaluated for the inhibitory potency on the production of nitric oxide (NO), inducible nitric oxide synthase (iNOS) activity, and the generation of prostaglandin E2 (PEG2).(Z)-N-(3- Chlorophenyl)-2-(4-((2, 4-dioxothiazolidin-5-ylidene) methyl) phenoxy) acetamide (3I), superior to the commercial anti-inflammatory drug indomethacin, significantly inhibited ...