Synthesis and biological activities of 2-pyrimidinone nucleosides. 2. 5-Halo-2-pyrimidinone 2'-deoxyribosides

…, HC Shih, YC Cheng, TJ Bardos

Index: Efange, Simon M. N.; Alessi, Elaine M.; Shih, H. C.; Cheng, Yung-Chi; Bardos, Thomas J. Journal of Medicinal Chemistry, 1985 , vol. 28, # 7 p. 904 - 910

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Citation Number: 41

Abstract

Method B. The direct radioiodination of borono analogues wa~ accomplished as follows. A solution of (E)-1-borono-1-penten-5yl-trisubstituted onium iodide (25 pmol, prepared by general procedure 1) and Na1251 (10-15 mCi, 3.8 mg, 25 pmol) in 50% aqueous THF (3 mL) was stirred with chloramine-T (7 mg, 25 pmol) for 30 min in the dark. Excess NaI (30 mg, 0.2 mmol) was added, and the reaction solution was stirred for an additional 10 min. The ...