Stereospecific synthesis of new 5??substituted 6??methyl??4, 5??dihydro??2H??pyridazin??3??ones. X??ray assignment study

…, JD Couquelet, JM Couquelet…

Index: Taoufik, J.; Couquelet, J. D.; Couquelet, J. M.; Carpy, A. Journal of Heterocyclic Chemistry, 1984 , vol. 21, p. 305 - 310

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Citation Number: 12

Abstract

Abstract Reaction of hydrazine hydrate with 4, 5-dihydro-3H-4-acetyl furan-2-ones I led to ring opening and rearrangement into 6-methyl-4, 5-dihydro-2H-pyridazin-3-ones II (1–20), the structure of which was determined by spectroscopic methods (ir, 1 H and 13 C nmr). An X-ray crystal structure study of compound 2 supports the assignment of configuration erythro (5RS, 7SR) for pyridazinones II. Stereochemical courses of this new synthetic route are ...