New imidazo [1, 2-a] pyrazine derivatives with bronchodilatory and cyclic nucleotide phosphodiesterase inhibitory activities

O Vitse, F Laurent, TM Pocock, V Bénézech…

Index: Vitse, Olivier; Laurent, Florence; Pocock, Tristan M.; Benezech, Veronique; Zanik, Lahcen; Elliott, Keith R. F.; Subra, Guy; Portet, Karine; Bompart, Jacques; Chapat, Jean-Pierre; Small, Roger C.; Michel, Alain; Bonnet, Pierre-Antoine Bioorganic and Medicinal Chemistry, 1999 , vol. 7, # 6 p. 1059 - 1065

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Citation Number: 37

Abstract

New imidazo [1, 2-a] pyrazine derivatives have been synthesized either by direct cyclization from pyrazines or by electrophilic substitutions. The presence of electron donating groups on position 8 greatly enhances the reactivity of the heterocycle towards such reactions on position 3 of the heterocycle. The activities of these derivatives in trachealis muscle relaxation and in inhibiting cyclic nucleotide phosphodiesterase (PDE) isoenzyme types III ...