The successful use of sulfanilamide and its derivatives in chemotherapy made it desirable to prepare quinoline analogs of two basic types, namely, 5-aminoquinoline-8-sulfonamide (I) and 8-aminoquinoline-5-sulfonamide (11). The following methods for the preparation of these analogs were tried without success:(1) the sulfonation of 8-aminoquinoline, 8- hydroxyquinoline and their derivatives with sulfuric acid2 and chlorosulfonic acid3 and the ...
