Synthesis and antimicrobial activity of 3-vinylthio-1, 2, 4-triazoles

BV Trzhtsinskaya, GG Skvortsova, YA Mansurov…

Index: Trzhtsinskaya, B. V.; Skvortsova, G. G.; Mansurov, Yu. A.; Buchin, P. I.; Viderker, M. G. Pharmaceutical Chemistry Journal, 1982 , vol. 16, # 12 p. 886 - 888 Khimiko-Farmatsevticheskii Zhurnal, 1982 , vol. 16, # 12 p. 1466 - 1468

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Citation Number: 3

Abstract

Theyield of (V) was raised to 80% by adding 20~-of water to the reaction mixture. Increasing the reaction temperature from 160 to! 80~ resulted in more extensive vinylation. Under these condition, in addition tD the triazole (V), liquid products were obtained which from their IR and PMR spectra were mixtures of isomers with two vinyl groups on different heteroatoms. Replacement of the methyl group in the 5-position of the triazole ring by a furyl substituent ...