Tetrahedron Letters

Facile preparation of highly-functionalized, nitrogen-bearing diarylmethanes

JR Schmink, MT Tudge

Index: Schmink, Jason R.; Tudge, Matthew T. Tetrahedron Letters, 2013 , vol. 54, # 1 p. 15 - 20

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Citation Number: 16

Abstract

A palladium-catalyzed cross coupling of nitrogen bearing heterocyclic chloromethyl derivatives with aryl and heteroaryl boronic acids has been developed. In almost all cases, highly efficient cross-couplings were observed at ambient temperature, mitigating unwanted thermally induced side-reactions. The comprehensive substrate scope and respectable yields highlight the synthetic utility of this reaction.