Synthesis of (S)-and (R)-4 [(methoxycarbonyl) methyl]-2-azetidinone by chemicoenzymic approach

M Ohno, S Kobayashi, T Iimori, YF Wang…

Index: Ohno, Masaji; Kobayashi, Susumu; Iimori, Takamasa; Wang, Yi-Fong; Izawa, Toshio Journal of the American Chemical Society, 1981 , vol. 103, # 9 p. 2405 - 2406

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Citation Number: 150

Abstract

to be a versatile intermediate of the carbapenem nuclei on the basis of previous and a combination of enzymatic and chemical procedures was taken as our synthetic strategy. Cohen and Khedouri showed that a-chymotrypsin hydrolyzes the pro-S ester group of diethyl@-acetamidoglutarate. 6 However, the acetamido compound was considered not a good candidate for our purpose, since it may cause difficulty in further hydrolysis of the ...