Synthesis and hybridization properties of the conjugates of oligonucleotides and stabilization agents—II

…, E Sottofattori, T Grandi, M Mazzei, DS Pyshnyi…

Index: Balbi; Sottofattori; Grandi; Mazzei; Pyshnyi, Dmitri S.; Lokhov, Sergej G.; Lebedev, Alexander V. Bioorganic and Medicinal Chemistry, 1997 , vol. 5, # 10 p. 1903 - 1910

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Citation Number: 7

Abstract

New pyranone derivatives having tri-or pentamethylenamine linker functions were synthesized. These derivatives were covalently attached through the 5′-phosphoramide linkage to heptanucleotide pd (CCAAACA). Complementary complexes of the octanucleotide pd (TGTTTGGC) and above oligonucleotide conjugates were tested for their thermodynamic response. The Tm data and thermodynamic parameters for complex ...