Studies on Cerebral Protective Agents. X. Synthesis and Evaluation of Anticonvulsant Activities for Novel 4, 5, 6, 7-Tetrahydrothieno (3, 2-c) pyridines and Related …

…, K SHIRAKAWA, H NAKANISHI, T KINOSHITA…

Index: Ohkubo, Mitsuru; Kuno, Atsushi; Katsuta, Kiyotaka; Ueda, Yoshiko; Shirakawa, Kiyoharu; Nakanishi, Hajime; Kinoshita, Takayoshi; Takasugi, Hisashi Chemical and Pharmaceutical Bulletin, 1996 , vol. 44, # 4 p. 778 - 784

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Citation Number: 8

Abstract

Novel 4, 5, 6, 7-tetrahydrothieno [3, 2-c] pyridines, 1-thienyl-1, 2, 3, 4- tetrahydroisoquinolines and related compounds, in which the benzene rings of (+)-1 (FR115427) were replaced with heteroaromatic rings such as thiophene, furan, benzothiophene and indole, were synthesized and evaluated for anticonvulsant activity against icv N-methyl-D-Aspartate (NMDA)-induced seizures in mice, Among these ...