The antimalarial activity of chloroquine-pyrazole analogues, synthesized from the reaction of 1, 1, 1-trifluoro-4-methoxy-3-alken-2-ones with 4-hydrazino-7-chloroquinoline, has been evaluated in vitro against a chloroquine resistant Plasmodium falciparum clone. Parasite growth in the presence of the test drugs was measured by incorporation of [3H] hypoxanthine in comparison to controls with no drugs. All but one of the eight (4, 5- ...
