The manufacture of a homochiral 4-silyloxycyclopentenone intermediate for the synthesis of prostaglandin analogues

JP Henschke, Y Liu, X Huang, Y Chen…

Index: Armstead, David A.; Mann, John Synthetic Communications, 1985 , vol. 15, # 13 p. 1147 - 1152

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Citation Number: 12

Abstract

... Volume: Page: ... 1 was responsible, through chiral induction, for the stereochemistry of up to three chiral centres formed in the subsequent synthetic steps ... isomer was reduced to 13 mol% upon the use of sodium ylide 10b, prepared with NaHMDS, in THF at −15 °C ...