Abstract The Thorpe-Ziegler intramolecular cyclization of 2-RCH 2 S-, 2-RCH 2 S (O)-, and 2- RCH 2 SO 2-substituted nicotinic acid esters and nitriles (R is alkyl, aryl, and 2-thienyl) upon the action of potassium tert-butoxide has been studied. The reaction results in the formation