3-Substituted anilines as scaffolds for the construction of glutamine synthetase and DXP-reductoisomerase inhibitors

…, S Salisu, GL Blatch, C Kenyon, PT Kaye

Index: Mutorwa, Marius; Salisu, Sheriff; Blatch, Gregory L.; Kenyon, Colin; Kaye, Perry T. Synthetic Communications, 2009 , vol. 39, # 15 p. 2723 - 2736

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Citation Number: 6

Abstract

Abstract Access to a series of truncated ATP analogs, as potential anti-tuberculosis agents, has been explored via alkylation and acylation of 3-aminophenol, whereas chloroacetylation, using chloroacetyl chloride, and subsequent Arbuzov phosphonation of a series of 3-substituted anilines have afforded a series of phosphonate derivatives as potential antimalarial agents.