In search of more potent anticancer agents, 15 nitric oxide (NO)-donating thalidomide analogues, 6a, 6b, 8a–8e, and 13a–13h, were designed and synthesized. Cytotoxicity of these compounds was evaluated in vitro against three human tumor cell lines (HepG2, A549, and PC-3). The results indicated that 13a–13d exhibited notable anticancer activities comparable to or stronger than that of 5-fluorouracil (5-FU). Structure–activity relationships ...
![4-[[4-(benzenesulfonyl)-5-oxido-1,2,5-oxadiazol-5-ium-3-yl]oxy]but-2-yn-1-ol Structure](https://image.chemsrc.com/caspic/172/452095-56-6.png)