Synthesis and preliminary in vitro biological activity of non-steroidal cytotoxic estrogens designed for the treatment of breast cancer

G Bérubé, P Wheeler, CHJ Ford…

Index: Berube; Wheeler; Ford; Gallant; Tsaltas Canadian Journal of Chemistry, 1993 , vol. 71, # 9 p. 1327 - 1333

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Citation Number: 19

Abstract

The development of resistance to endocrine therapy as well as chemotherapy is presently a major problem in the treatment of breast cancer. To minimize this obstacle, new, more selective and potent, chemotherapeutic agents should be designed. One way to improve selectivity is to link a cytotoxic moiety to a molecule possessing an affinity to the estrogen receptor (ER). The latter would be used to direct the cytotoxic portion of the molecule ...

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