A Macrocyclic Enzyme Model System. Deacylation of p-Nitrophenyl Carboxylates as Effected by a [20] Paracyclophane Bearing an Imidazole Group

Y Murakami, Y Aoyama, M Kida, A Nakano

Index: Murakami,Y. et al. Bulletin of the Chemical Society of Japan, 1977 , vol. 50, p. 3365 - 3371

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Citation Number: 26

Abstract

The kinetic effect of a [20] paracyclophane bearing an imidazole moiety (1) on the deacylation of various p-nitrophenyl carboxylates was investigated in 10.9%(v/v) ethanol- 1.0%(v/v) dioxane-water of μ 0.10 (KCl) at 40.0±0.1° C. The facile reaction of 1 with a hydrophobic ester resulted in the accumulation of the N Im-acyl derivative of 1 along the progress of reaction, and the rate of regeneration of 1 (turnover) was negligibly small ...