Abstract: Solvent effects on the ring closure of some thiol amides and hydroxy acids have been examined using sulfolane as a solvent. In general, the relative reactivities in the dipolar aprotic solvent parallel those in water, but there are some deviations. Solvent effects on rates of the individual reactions studied here as well as on related reactions are generally modest, but examples of changes in rate as large as IO6 with changing solvent are noted ...
