Structurally modified nucleosides in which a methylene carbon replaces the oxygen of furanose (carbocyclic nucleosides) have been widely investigated for their medicinal properties 1 and we have previously reported on the one-carbon homologation of cyclobutanones protocol as an entry to such systems. 2 As a consequence of this structural modification the glycosidic bond becomes more resistant to nucleoside phosphorylase and hydrolase degradations. ...
