A versatile one-pot nitro-Mannich/lactamization cascade for the direct synthesis of 1,3,5-trisubstituted 4-nitropyrrolidin-2-ones has been developed. The reaction is easy to perform and broad in scope, and high levels of diastereoselectivity can be achieved. ... In recent times, the nitro-Mannich(1) reaction has emerged as a powerful synthetic tool for the construction of important intermediates and building blocks. We recently described(2) an efficient nitro-Mannich/ ...
