Synthesis of 2, 6-Dimethyltropone-A New, Convenient Methodology from 2, 6-Dimethylcyclohexanone

…, A Bohac, M Salisova, G Addova, M Rosenblum

Index: Almassy, Ambroz; Pazicky, Marek; Bohac, Andrej; Salisova, Marta; Addova, Gabriela; Rosenblum, Myron Synthesis, 2002 , # 12 p. 1695 - 1700

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Citation Number: 3

Abstract

Abstract Until now, 2, 6-dialkyltropones have not been described. 2, 6-Dimethyltropone (5) represents an appropriate material for synthesis of naturally occurring antiviral compounds. A new, convenient method for synthesis of 2, 6-dimethyltropone (5) from 2, 6- dimethylcyclohexanone in five optimized steps and 52% overall yield has been developed. Trimethylsilyl enol ether 1, prepared from 2, 6-dimethylcyclohexan-1-one, was treated with ...