Organic letters

Large-scale, protection-free synthesis of Se-adenosyl-L-selenomethionine analogues and their application as cofactor surrogates of methyltransferases

IR Bothwell, M Luo

Index: Winter, Jaclyn M.; Chiou, Grace; Bothwell, Ian R.; Xu, Wei; Garg, Neil K.; Luo, Minkui; Tang, Yi Organic Letters, 2013 , vol. 15, # 14 p. 3774 - 3777

Full Text: HTML

Citation Number: 12

Abstract

S-Adenosyl-l-methionine (SAM) analogues have previously demonstrated their utility as chemical reporters of methyltransferases. Here we describe the facile, large-scale synthesis of Se-alkyl Se-adenosyl-l-selenomethionine (SeAM) analogues and their precursor, Se-