Tetrahedron

Synthesis of 4-aryl-5-hydroxy-and 5-aryl-4-hydroxypyridazin-3 (2H)-ones and their use in the preparation of 4, 5-diarylpyridazin-3 (2H)-ones and hitherto unknown …

…, K Monsieurs, KTJ Loones, GLF Lemière, R Dommisse…

Index: Maes, Bert U.W; Monsieurs, Katrien; Loones, Kristof T.J; Lemiere, Guy L.F; Dommisse, Roger; Matyus, Peter; Riedl, Zsuzsanna; Hajos, Gyoergy Tetrahedron, 2002 , vol. 58, # 48 p. 9713 - 9721

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Citation Number: 18

Abstract

Easily accessible 2-substituted 4-aryl-5-methoxy-and 2-substituted 5-aryl-4- methoxypyridazin-3 (2H)-ones were transformed into the corresponding aryl- hydroxypyridazin-3 (2H)-ones by alkaline hydrolysis. The use of these compounds in the synthesis of 2-substituted 4, 5-diarylpyridazin-3 (2H)-ones with two differently substituted aryl groups was investigated. Two aryl-hydroxypyridazin-3 (2H)-ones, 2-(2-benzyl-5- ...