Tetrahedron Letters

The rhodium-catalysed 1, 2-addition of arylboronic acids to aldehydes and ketones with sulfonated S-Phos

JR White, GJ Price, PK Plucinski, CG Frost

Index: White, James R.; Price, Gareth J.; Plucinski, Pawel K.; Frost, Christopher G. Tetrahedron Letters, 2009 , vol. 50, # 52 p. 7365 - 7368

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Citation Number: 15

Abstract

The rhodium-catalysed 1, 2-addition of arylboronic acids to aryl aldehydes has been accomplished in high yield using sulfonated S-Phos, a water-soluble biaryl phosphine ligand which allows for catalyst recycling. The catalytic protocol has also been successful in the challenging arylation of ketones.