New and more potent antifungal disulfides

…, MO Baerlocher, RF Langler, SL MacQuarrie…

Index: Baerlocher, Felix Jakob; Baerlocher, Mark Otto; Langler, Richard Francis; MacQuarrie, Stephanie Lee; Marchand, Maurice Emile Australian Journal of Chemistry, 2000 , vol. 53, # 1 p. 1 - 5

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Citation Number: 22

Abstract

Abstract From a design principle described in an earlier paper, a new series of substituted aryl methyl disulfides have been prepared and tested against Aspergillus niger and Aspergillus flavus. Methyl p-nitrophenyl disulfide is more potent (by an order of magnitude) than the fungitoxic natural product (CH 3 SCH 2 S) 2. With the present rationale in hand, one can anticipate which Polycarpamine is an effective antifungal agent. Keywords: Antifungal; ...