Inhibition of tyrosinase activity by N, N-unsubstituted selenourea derivatives

…, K Lee, SY Choi, JH Park, H Ishihara, SY Kim

Index: Ha, Sang Keun; Koketsu, Mamoru; Lee, Kunho; Choi, Sang Yoon; Park, Ji-Ho; Ishihara, Hideharu; Kim, Sun Yeou Biological and Pharmaceutical Bulletin, 2005 , vol. 28, # 5 p. 838 - 840

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Citation Number: 34

Abstract

This study investigated inhibitory effects of N, N-unsubstituted selenourea derivatives on tyrosinase activity. Three types of N, N-unsubstituted selenoureas derivatives exhibited inhibitory effect on dopa (3, 4-dihydroxyphenylalanine) oxidase activity of mushroom tyrosinase. Compound D at a concentration of 200 μM exhibited 55.5% of inhibition on dopa oxidase activity of mushroom tyrosinase. This inhibitory effect was higher than that of kojic ...