Abstract The general ability of appropriate pyridyl compounds (aldehyde or ketone) to undergo Friedländer condensation to give different 1, 7-naphthyridines has been demonstrated. 2, 4-Disubstituted 1, 7-naphthyridine 8 was prepared from 3-amino-4- acetylpyridine (6) and ketone 4 (82%). The Friedländer self-condensation of pyridyl substrate 6 is reported, as well. The dimer product, 2-(3-aminopyridin-4-yl)-4-methyl-1, 7- ...
