Tetrahedron letters

Copper (I)-catalyzed asymmetric alkene aziridination mediated by PhI (OAc) 2: a facile one-pot procedure

HL Kwong, D Liu, KY Chan, CS Lee, KH Huang…

Index: Kwong, Hoi-Lun; Liu, Di; Chan, Ka-Yee; Lee, Chi-Sing; Huang, Ka-Hung; Che, Chi-Ming Tetrahedron Letters, 2004 , vol. 45, # 20 p. 3965 - 3968

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Citation Number: 56

Abstract

A facile one-pot procedure for copper-catalyzed PhI (OAc) 2-mediated asymmetric alkene aziridination had been developed. Commercially available PhI (OAc) 2 and sulfonamides were used to generate the nitrene precursors (PhI NR) in situ for olefin aziridination. This one-pot procedure had been optimized using 4-nitrobenzenesulfonamide as the nitrene source. With 5mol% of the chiral copper catalyst, these conditions afforded 94% yield of ...

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