e.g. Filippa Pettersson or Cancer Res. 75(6) , 1102-12, (2015) or 10.1002/anie.201600521
Enantioselective α-arylation of aldehydes via organo-SOMO catalysis. An ortho-selective arylation reaction based on an open-shell pathway
…, J Kong, BN Laforteza, DWC MacMillan
Index: Conrad, Jay C.; Kong, Jongrock; Laforteza, Brian N.; MacMillan, David W. C. Journal of the American Chemical Society, 2009 , vol. 131, # 33 p. 11640 - 11641
The intramolecular α-arylation of aldehydes has been accomplished using singly occupied molecular orbital (SOMO) catalysis. Selective oxidation of chiral enamines (formed by the condensation of an aldehyde and a secondary amine catalyst) leads to the formation of a 3π- electron radical species. These chiral SOMO-activated radical cations undergo enantioselective reaction with an array of pendent electron-rich aromatics and ...
