Tetrahedron: Asymmetry

Enzymatic resolution of (±)-cis-2-aminocyclopentanol and (±)-cis-2-aminocyclohexanol

A Luna, C Astorga, F Fülöp, V Gotor

Index: Luna, Amparo; Astorga, Covadonga; Fueloep, Ferenc; Gotor, Vicente Tetrahedron Asymmetry, 1998 , vol. 9, # 24 p. 4483 - 4487

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Citation Number: 28

Abstract

In recent years, we have been exploring the use of enzymes, and particularly lipases, in organic solvents, for the synthesis and resolution of nitrogen-containing organic compounds.[1]1,2-Amino alcohols were resolved via an enzymatic aminolysis reaction,[2]although the enzymatic transesterification of N-protected amino alcohols has been reported by ourselves [3]and others[4]as an efficient procedure for the resolution of some amino alcohols. ... Surprisingly, very little attention ...