Abstract Condensation of adenine and its substituted derivatives with 1, 1-dialkoxy-2- bromoalkanes afforded substituted 2-(adenin-9-yl)-1, 1-dialkoxyalkanes I and IV. Acid hydrolysis of I or IV, followed by reaction with alkali metal cyanides and acid hydrolysis, gave substituted 3-(adenin-9-yl)-2-hydroxyalkanoic acids II, Vand VI. Methyl esters of these compounds (VIII) were converted into 3-(adenin-9-yl) alkane-1, 2-diols IX by reduction ...
