An efficient route for the synthesis of a new class of pyrido [2, 3-d] pyrimidine derivatives

…, J Zhang, R Jia, B Jiang, Y Zhang, H Jiang

Index: Tu, Shujiang; Zhang, Junyong; Jia, Runhong; Jiang, Bo; Zhang, Yan; Jiang, Hong Organic and Biomolecular Chemistry, 2007 , vol. 5, # 9 p. 1450 - 1453

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Citation Number: 22

Abstract

A new reaction of 4-arylidene-3-methylisoxazol-5 (4H)-one or 4-arylidene-2-phenyloxazol-5 (4H)-one with 2, 6-diaminopyrimidin-4 (3H)-one is described and a number of new pyrido [2, 3-d] pyrimidine-4, 7-dione derivatives are synthesized. This protocol has the advantages of good yields, broad substrate scope and simple work-up.