Abstract A simple and convenient one-pot synthesis of (1 R, 4 S, 6 R)-4-isopropenyl-1, 3, 3- trimethyl-7-oxabicyclo [4.1. 0] heptan-2-one was developed consisting in a thermodynamic methylation of carvone (NaH, MeI, THF, 20° C) followed by the epoxidation with alkalinized hydrogen peroxide. The reduction of the obtained epoxyketone with sodium borohydride proceeded stereoselectively to give a β-alcohol. The attempts to convert its isopropenyl ...
