Abstract The new concept developed in this study is the design of poly (ethylene glycol)(PEG)-coated biodegradable nanoparticles coupled to folic acid to target the folate- binding protein; this molecule is the soluble form of the folate receptor that is overexpressed on the surface of many tumoral cells. For this purpose, a novel copolymer, the poly [aminopoly (ethylene glycol) cyanoacrylate-co-hexadecyl cyanoacrylate][poly (H 2 ...