Dimeric 1, 4-dihydropyridines as calcium channel antagonists

AF Joslyn, E Luchowski, DJ Triggle

Index: Joslyn, Alan F.; Luchowski, Elizabeth; Triggle, David J. Journal of Medicinal Chemistry, 1988 , vol. 31, # 8 p. 1489 - 1492

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Citation Number: 23

Abstract

A series of l, n-alkanediylbis (l, 4-dihydropyridines)(n= 2, 4, 6, 8, 10, 12) bridged at C3 of 2, 6- dimethyl-3-carboxy-5-carbethoxy-4-(3-nitrophenyl)-1, 4-dihydropyridine were synthesized and evaluated in a radioligand binding assay,[3H] nitrendipine in intestinal smooth muscle, as Ca2+ channel ligands. Binding activity was comparable to that of nitrendipine itself but independent of chain length, suggesting the lack of a major binding contribution by the ...