A series of l, n-alkanediylbis (l, 4-dihydropyridines)(n= 2, 4, 6, 8, 10, 12) bridged at C3 of 2, 6- dimethyl-3-carboxy-5-carbethoxy-4-(3-nitrophenyl)-1, 4-dihydropyridine were synthesized and evaluated in a radioligand binding assay,[3H] nitrendipine in intestinal smooth muscle, as Ca2+ channel ligands. Binding activity was comparable to that of nitrendipine itself but independent of chain length, suggesting the lack of a major binding contribution by the ...
