Synthesis and Evaluation of 1-Arylsulfonyl-3-piperazinone Derivatives as a Factor Xa Inhibitor. II. Substituent Effect on Biological Activities.

H Nishida, Y Miyazaki, T Mukaihira, F Saitoh…

Index: Nishida, Hidemitsu; Miyazaki, Yutaka; Mukaihira, Takafumi; Saitoh, Fumihiko; Fukui, Miyuki; Harada, Kousuke; Itoh, Manabu; Muraoka, Aki; Matsusue, Tomokazu; Okamoto, Atsushi; Hosaka, Yoshitaka; Matsumoto, Miwa; Ohnishi, Shuhei; Mochizuki, Hidenori Chemical and Pharmaceutical Bulletin, 2002 , vol. 50, # 9 p. 1187 - 1194

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Citation Number: 21

Abstract

Intravascular clot formation is an important event in a number of cardiovascular diseases. The prevention of blood coagulation has become a major target for new therapeutic agents. Factor Xa (FXa) is a trypsin-like serine protease that plays a key role in the blood coagulation cascade and represents an attractive target for anticoagulant drug development. We have investigated substituents in the central part of a lead compound (3: M55113), ...