Tetrahedron Letters

An efficient catalytic method for the Beckmann rearrangement of ketoximes to amides and aldoximes to nitriles mediated by propylphosphonic anhydride (T3P®)

JK Augustine, R Kumar, A Bombrun, AB Mandal

Index: Augustine, John Kallikat; Kumar, Rajesha; Bombrun, Agnes; Mandal, Ashis Baran Tetrahedron Letters, 2011 , vol. 52, # 10 p. 1074 - 1077

Full Text: HTML

Citation Number: 64

Abstract

An efficient method for the Beckmann rearrangement of ketoximes to amides mediated by a catalytic amount (15mol%) of propylphosphonic anhydride (T3P®) is described. Aldoximes underwent second order Beckmann rearrangement to provide the corresponding nitriles in excellent yields on reacting with T3P (15mol%) at room temperature. The main advantages of this environmentally friendly protocol include procedural simplicity, and particularly ...