New Rev-transport inhibitor with anti-HIV activity from Valerianae Radix

N Murakami, Y Ye, M Kawanishi, S Aoki, N Kudo…

Index: Murakami, Nobutoshi; Ye, Ying; Kawanishi, Motoyuki; Aoki, Shunji; Kudo, Nobuaki; Yoshida, Minoru; Nakayama, Emi E.; Shioda, Tatsuo; Kobayashi, Motomasa Bioorganic and Medicinal Chemistry Letters, 2002 , vol. 12, # 20 p. 2807 - 2810

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Citation Number: 56

Abstract

Bioassay-guided separation by use of the fission yeast expressing NES of Rev, a HIV-1 viral regulatory protein, resulted in isolation of valtrate (1) as a new Rev-transport inhibitor from the nucleus to cytoplasm from Valerianae Radix. Valtrate (1) also inhibited the p-24 production of HIV-1 virus without showing any cytotoxicity against the host MT-4 cells.