Synthesis of resveratrol acrylamides derivatives and biological evaluation of their anti-proliferative effect on cancer cell lines

BF Ruan, SQ Wang, XL Ge…

Index: Ruan, Ban-Feng; Wang, Si-Qi; Ge, Xiao-Lin; Yao, Ri-Sheng Letters in Drug Design and Discovery, 2014 , vol. 11, # 1 p. 2 - 9

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Citation Number: 3

Abstract

A new series of resveratrol acrylamides amine derivatives was designed, synthesized, and evaluated for their anti-proliferative activity against three cancer cell lines including human chronic myelocytic leukemia cell K562, human hepatoma HuH-7 and human lung carcinoma A549. Most of the compounds showed superior activity against three cell lines when compared to parent resveratrol. C13 had the best anti-tumor activity against the HuH-7 cell ...