Simple methodology for syntheses of porphyrins possessing multiple peripheral substituents with an element of symmetry

LT Nguyen, MO Senge, KM Smith

Index: Nguyen, Liem T.; Senge, Mathias O.; Smith, Kevin M. Journal of Organic Chemistry, 1996 , vol. 61, # 3 p. 998 - 1003

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Citation Number: 81

Abstract

New methodology was developed for synthesis of regiochemically pure porphyrins with D 2 h symmetry (eg 9) via tetramerization reactions involving two different pyrroles. The two pyrrole components were a 2, 5-diunsubstituted pyrrole (eg 11) and a 2, 5-bis [(N, N- dimethylamino) methyl] pyrrole (eg 10), the latter being formed from a 2, 5-di-unsubstituted pyrrole by treatment with excess Eschenmoser's reagent (N, N- ...