The capacity factors, k', of 11 cyclic dipeptides (XY) including diastereomers have been determined on an RP-HPLC column in 30% and 50% methanol and lo%, 30%, and 50% acetonitrile solutions. These factors are roughly correlated with hydrophobic parameters, such as octanolwater partition coefficients estimated and k 'values for alcohols. For a pair of diastereomers of cyclic (LXL-Phe) and (LXD-Phe) derivatives k% L is larger than k'LD, and ...
