Abstract A set of 27-to 39-membered pyridine macrocycles 2 and 3 has been synthesized by Williamson ether synthesis or ring-closing metathesis. The pyridines are 2, 6-disubstituted to allow endo interactions. In addition to the length, also thenature of the aliphatic chain was varied: saturated (2) and unsaturated (3).
[Fuller, Anne-Marie L.; Leigh, David A.; Lusby, Paul J.; Slawin, Alexandra M. Z.; Walker, D. Barney Journal of the American Chemical Society, 2005 , vol. 127, # 36 p. 12612 - 12619]
