Efficient synthesis of benzamide riboside, a potential anticancer agent

LF Bonnac, GY Gao, L Chen, SE Patterson…

Index: Bonnac, Laurent F.; Gao, Guang-Yao; Chen, Liqiang; Patterson, Steven E.; Jayaram, Hiremagalur N.; Pankiewicz, Krzysztof W. Nucleosides, Nucleotides and Nucleic Acids, 2007 , vol. 26, # 10-12 p. 1249 - 1253

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Citation Number: 6

Abstract

Benzamide riboside (BR) belongs to the C-nucleoside family of nucleosides, which has a ribofuranosyl moiety linked to the heterocyclic or aromatic base through a stable carbon-carbon bond rather than a carbon-nitrogen bond as in natural nucleosides [ 1 1. Gharehbaghi , K. , Grunberger , W. and Jayaram , HN 2002. Studies on the mechanism of action of benzamide riboside: A novel inhibitor of IMP dehydrogenase. Curr. Med. Chem., 9: 743–748. ... View all references , 2 ...