e.g. Filippa Pettersson or Cancer Res. 75(6) , 1102-12, (2015) or 10.1002/anie.201600521
Michael addition of acyclic lithium 1, 3-dien-2-olates with α, β-unsaturated esters, ketones, and diesters
S Kanemasa, M Kumegawa, E Wada…
Index: Kanemasa, Shuji; Kumegawa, Masahiro; Wada, Eiji; Nomura, Masafumi Bulletin of the Chemical Society of Japan, 1991 , vol. 64, # 10 p. 2990 - 3004
The Michael addition of lithium 1, 3-dien-2-olates with α, β-unsaturated carbonyl compounds is described. With α, β-unsaturated esters the reaction was reversible even at− 78° C, while kinetically controlled with α, β-unsaturated ketones or alkylidenemalonates. At room temperature, the initially formed Michael adducts undergo subsequent intramolecular Michael addition to give substituted cyclohexanone derivatives in a highly stereoselective ...