Hitostuyanagis group22 has recently reported the preparation of 1,2,4-triazole derivatives, starting from Boc-thionotripeptides, but performing cyclisation only with formic hydrazide. This reaction is very attractive, owing to the mild reaction conditions used for the heterocycle formation, which contained the condensation of a thionotripeptide with an excess of formic hydrazide at room temperature in the presence of mercury(II) acetate. In order to extend the synthetic scope ...
