Design and synthesis of 3'-and 5'-O-(3-benzenesulfonylfuroxan-4-yl)-2'-deoxyuridines: Biological evaluation as hybrid nitric oxide donor-nucleoside anticancer agents

S Moharram, A Zhou, LI Wiebe…

Index: Moharram, Sameh; Zhou, Aihua; Wiebe, Leonard I.; Knaus, Edward E. Journal of Medicinal Chemistry, 2004 , vol. 47, # 7 p. 1840 - 1846

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Citation Number: 49

Abstract

A group of 3'-O-and 5'-O-(3-benzenesulfonylfuroxan-4-yl)-2'-deoxyuridines possessing a variety of substituents (H, Me, I, F, CF3) at the C-5 position of the nucleoside moiety were synthesized for evaluation as hybrid anticancer agents that have the ability to simultaneously release cytotoxic nitric oxide (⊙ NO). Incubation of these nitric oxide donor- nucleoside conjugates in the presence of 18 mM l-cysteine released a high percentage of ...