Synthesis and pharmacological properties of certain 3, 4-dihydroxypiperidines

…, EV Yushkevich, LA Melentovich, AP Lugovskii

Index: Stanishevskii, L. S.; Zakharevskii, A. S.; Zvonok, A. M.; Yushkevich, E. V.; Melentovich, L. A.; Lugovskii, A. P. Pharmaceutical Chemistry Journal, 1990 , vol. 24, # 2 p. 102 - 106 Khimiko-Farmatsevticheskii Zhurnal, 1990 , vol. 24, # 2 p. 114 - 117

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Abstract

The reduction of 6-aryl-3-hydroxypiperidine-4-ones X-XIV by sodium borohydride in isopropyl alcohol primarily results in the formation of 6-aryl-3e, 4e-dihydroxy-le, 3a- dimethylpiperidines (X~'I-XX). Furthermore, the stereochemistry of the process is the same as in the case of the 6-phenyl analog [7].